The pi-SEE-HSelMQC method completely suppresses lipid and water with potential clinical applications in disease diagnosis and therapeutic interventions. 4 illustrates an example Sel-ZQC pulse sequences for imaging metabolite distributions of lactate. The method detects the lactate signal in a single shot making it less susceptible to motion and instability than difference and phase cycling methods. In vivo one-dimensional pi-SEE-HSelMQC CSI images of lactate and choline, acquired from the MDA-MB-231 human breast cancer xenograft in a nude mouse, as well as two-dimensional pi-SEE-HSelMQC imaging of lactate and choline acquired from the PC3 human prostate cancer xenograft in a nude mouse, also had opposite image offsets, shifted away from the spurious residual water signals in the image center. Of the various MQ lactate editing techniques, the doubly frequency selective multiple quantum coherence transfer (SelMQC) technique has several advantages. The lactate and choline images from a yogurt phantom displayed opposite image offsets without image overlapping.
SELECTIVE MULTIPLE QUANTUM COHERENCE LACTATE PC
He Q Shungu DC van Zijl PC Bhujwalla ZM Glickson JD J Magn Reson B 1995 Mar 106(3):203-11. Work performed on phantoms showed good lactate detection (49) and lipid suppression (98) efficiencies. Single-scan in vivo lactate editing with complete lipid and water suppression by selective multiple-quantum-coherence transfer (Sel-MQC) with application to tumors. The choline-selective and lactate CH-selective RF pulses were phase incremented by 10° in opposite signs, synchronized with the phase-encoding steps. This study presents the use of a selective homonuclear multiple quantum coherence transfer sequence (SelMQCCSI), at 1.5 T, to better quantify lactate in the presence of lipids. On a Bruker 9.4T MRI spectrometer, the pi-SEE-HSelMQC sequence was implemented. lipid and water suppression by selective multiple-quantum-coherence transfer. Work performed on phantoms showed good lactate detection(49) and lipid suppression (98) efciencies. Abstract: Phase-incrementing MRSI (pi-MRSI) method has resolved overlapping biomarker images in the presence of a read-gradient. Thisstudy presents the use of a selective homonuclear multiple quantum coherence transfer sequence (SelMQC-CSI), at1.5 T, to better quantify lactate in the presence of lipids.
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